2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-129834
    Bilirubin Conjugate disodium 68683-34-1
    Bilirubin Conjugate disodium is a ditaurate derivative of Bilirubin. Bilirubin, a major end product of heme breakdown, is an important constituent of bile.
    Bilirubin Conjugate disodium
  • HY-132613
    Lumasiran sodium 1834612-06-4 99.21%
    Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .
    Lumasiran sodium
  • HY-133108
    Azadirachtin B 106500-25-8 99.17%
    Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties.
    Azadirachtin B
  • HY-143712
    Allolithocholic acid 2276-94-0 ≥98.0%
    Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver.
    Allolithocholic acid
  • HY-147246
    Berberine ursodeoxycholate 1868138-66-2 98.75%
    Berberine ursodeoxycholate (HTD1801), an ionic salt of Berberine and Ursodeoxycholic acid, is an orally active and potent hypolipidemic agent. Berberine ursodeoxycholate shows significantly great reduction in liver fat content. Berberine ursodeoxycholate has a broad spectrum of metabolic activity. Berberine ursodeoxycholate can be used for the research of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes.
    Berberine ursodeoxycholate
  • HY-147329
    RAGE 229 2143072-85-7 99.70%
    RAGE 229 is an orally active ctRAGE-DIAPH1 inhibitor. RAGE 229 can inhibit the intracellular RAGE signaling by inhibiting the interaction between the cytoplasmic tail of RAGE(ctRAGE) and Diaphanous-1(DIAPH1).
    RAGE 229
  • HY-148349
    PF-07258669 2755890-53-8 98.44%
    PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC50 of 13 nM (Ki=0.46 nM). PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa.
    PF-07258669
  • HY-150700
    RLX-33 2784577-71-3 99.79%
    RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome.
    RLX-33
  • HY-15258A
    Lesinurad sodium 1151516-14-1
    Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
    Lesinurad sodium
  • HY-153340
    I-152 311343-11-0 98.78%
    I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties.
    I-152
  • HY-156354
    GPR61 Inverse agonist 1 ≥98.0%
    GPR61 Inverse agonist 1 (Compound 1) is a GPR61 inverse agonist (IC50: 11 nM). GPR61 Inverse agonist 1 can be used for research of disorders of metabolism and body weight, such as obesity and cachexia.
    GPR61 Inverse agonist 1
  • HY-16343C
    NB-598 Maleate 155294-62-5
    NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 (Maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NB-598 Maleate
  • HY-B1402B
    Hydrocortisone hemisuccinate sodium 125-04-2 99.66%
    Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC).
    Hydrocortisone hemisuccinate sodium
  • HY-B1777A
    Spermine tetrahydrochloride 306-67-2 ≥98.0%
    Spermine tetrahydrochloride is an endogenous metabolite.
    Spermine tetrahydrochloride
  • HY-B2235A
    L-α-Lecithin (egg yolk), 75% 8002-43-5
    L-α-Lecithin (egg yolk), 75% is a kind of biological materials. L-α-Lecithin (egg yolk), 75% can be used for studying cell membrane structure, biofilm potential, liposome research, etc.
    L-α-Lecithin (egg yolk), 75%
  • HY-N0415S
    Trigonelline-d3 chloride 99.41%
    Trigonelline-d3 (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
    Trigonelline-d3 chloride
  • HY-P2297A
    TfR-T12 TFA 99.10%
    TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.
    TfR-T12 TFA
  • HY-P3016A
    Glutamate oxaloacetate aminotransferase, porcine heart 9000-97-9
    Glutamate oxaloacetate aminotransferase, porcine heart catalyzes the reversible reaction of L-aspartate and α-ketoglutarate into oxaloacetate and L-glutamate.
    Glutamate oxaloacetate aminotransferase, porcine heart
  • HY-100530C
    Sp-cAMPS sodium salt 142439-95-0 99.45%
    Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC50 of 40 μM.
    Sp-cAMPS sodium salt
  • HY-101203A
    GJ103 sodium 1459687-96-7 99.46%
    GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations.
    GJ103 sodium
Cat. No. Product Name / Synonyms Application Reactivity